SOPHiA GENETICS S.A. Q4 2025 Earnings Call Summary

1 week ago 3

Moby Intelligence

Tue, March 3, 2026 astatine 11:34 AM CST 3 min read

Achieved 22% full gross maturation successful Q4 2025, driven by a 31% summation successful objective gross arsenic the halfway concern re-accelerated toward humanities levels.
Processed astir 1 petabyte of genomic information successful 2025, doubling measurement from 2 years agone owed to a marketplace displacement toward ample broad panels and multi-omic analysis.
Expanded adjusted gross borderline by 140 ground points to 74.2% done a large architectural modernization that accrued compute capableness tenfold and reduced full genome investigation clip to nether 6 hours.
Secured 2 of the largest integrated wellness systems successful the US, representing a combined imaginable of 60,000 yearly genomic tests and 1 cardinal oncology/rare illness patients.
Maintained precocious level stickiness with annualized gross churn beneath 1% and a Net Promoter Score of 67, validating the decentralized AI deployment model.
Announced a enactment modulation with Ross Muken to go CEO successful July 2026, portion laminitis Jurgi Camblong moves to Executive Chairman to absorption connected method innovation.
Leveraged a divers information watercourse from 75 countries to motorboat 'Digital Twins' for lung cancer, enabling AI-driven virtual simulations for therapy selection.

Projecting 2026 gross betwixt $92 cardinal and $94 million, with maturation heavy back-half weighted arsenic grounds 2025 bookings modulation to regular usage.
Management anticipates a nett affirmative biopharma publication successful 2026 arsenic their communicative begins to resonate with elder members of apical 20 pharmaceutical companies, though they are not yet forecasting a melodramatic acceleration oregon 'hockey stick' maturation for that year.
Targeting adjusted EBITDA breakeven by the extremity of 2026 and affirmative adjusted EBITDA successful the 2nd fractional of 2027 by dropping 60% of incremental gross to the bottommost line.
Assuming continued ASP enlargement arsenic customers migrate to higher-value products similar MSK-ACCESS and Enhanced Exomes, contempt lower-ASP measurement maturation successful emerging markets.
Planning to clasp operating expenses level successful section currency by flattening organizational structures and optimizing discretionary spending.

Reported important adverse overseas speech impacts owed to a 14% appreciation of the Swiss franc, which inflated payroll and rent expenses successful US dollar terms.
Incurred $1.8 cardinal successful ineligible expenses related to patent litigation with Guardant Health; however, the Unified Patent Court precocious rejected Guardant's petition for provisional measures.
Strengthened liquidity by raising $15.5 cardinal done an ATM installation and expanding a recognition installation with Perceptive Advisors by $25 million.
Identified a grounds debased nett dollar retention of 115%, up from 104% successful the anterior year, driven by palmy cross-selling of further objective applications.