Oprah joins wave of celebrities who revealed dramatic weight loss in 2025

Celebrities person been striving for wellness successful 2025, with galore dropping important amounts of value — successful galore cases with the assistance of GLP-1 medications similar Ozempic.

Below are 4 A-list stars who shared their weight-loss journeys this year, with oregon without the assistance of medicine drugs.

No. 1: Oprah Winfrey

Long-time speech amusement big Oprah Winfrey was precocious featured successful an exclusive interrogation with People Magazine, during which she discussed her value nonaccomplishment and her caller book, "Enough: Your Health, Your Weight and What It’s Like to Be Free."

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Winfrey, 71, began taking a GLP-1 medicine successful 2023 but attempted to discontinue conscionable six months successful to spot if she could suffer value without it. Regardless of her fare and workout routines, the media mogul said she inactive gained backmost 20 pounds aft stopping the drug.

Oprah Winfrey is pictured successful February 2020 (left) and successful October 2025 (right). (Steve Jennings/Getty Images; Lanna Apisukh/WWD via Getty Images)

"It's going to beryllium a beingness thing," she shared. "I'm connected precocious humor unit medication, and if I spell disconnected the precocious humor unit medication, my humor unit is going to spell up. The aforesaid happening is existent now, I realize, with these medications. I’ve proven to myself [that] I request it."

Winfrey revealed that her default weight, astatine 211 pounds, was not healthy, arsenic she was pre-diabetic and had precocious cholesterol.

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The writer told People that she injects a GLP-1 weekly, and has besides paid retired of pouch for friends who could not spend the drug.

Winfrey added that the lack of nutrient sound "has fixed maine a quiescent spot that comes with everything I do. Everything is conscionable calmer and stronger."

Amy Schumer, Meghan Trainor and Oprah Winfrey (left to right) are among the celebrities who person revealed their value nonaccomplishment successful 2025. (Raymond Hall/GC Images; Chris Haston/WBTV via Getty Images; Theo Wargo/Getty Images)

Regardless of GLP-1 entree oregon tolerance, Winfrey encouraged those struggling with obesity that it is "not your fault."

"I privation radical to halt blaming [themselves] for genes and an situation [they] can’t control," she said. "I privation radical to person the information, immoderate you take to bash with it, whether you get the medications, oregon whether you privation to support dieting."

No. 2: Amy Schumer

Comedian Amy Schumer dropped 50 pounds aft being diagnosed with Cushing’s syndrome, a hormonal upset that tin origin utmost swelling, fatigue and perchance fatal complications.

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Schumer's translation sparked speech online, to which she responded successful a now-deleted Instagram station that unopen down speculation astir cosmetic enhancements.

"I didn’t suffer 30 lbs — I mislaid 50," she emphasized connected societal media, adding that she does not get Botox oregon filler.

Amy Schumer is pictured successful May 2024 astatine left, and connected the close aft her value nonaccomplishment successful 2025. (Marleen Moise/WireImage; Amy Schumer/Instagram)

Schumer doubled down that her value nonaccomplishment was not astir her appearance, but astir staying alive. She besides confirmed that she has utilized the GLP-1 medicine Mounjaro.

"Not to look hot, which does consciousness amusive and temporary," she said. "I did it to survive. I had a illness that makes your look highly puffy that tin termination you, but the net caught it and that illness has cleared."

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"Sorry for immoderate feeling it’s giving you that I mislaid that weight," she added. "I’ve had integrative country implicit the years and I usage [Mounjaro] … I’m pain-free. I tin [play] tag with my son."

The histrion besides addressed her shifting hormones, saying that she’s "happy to stock much if anyone has immoderate questions astir however I’m looking oregon feeling oregon wherever I americium successful my perimenopause process."

No. 3: Meghan Trainor

"All About That Bass" vocalist Meghan Trainor has besides confronted haters for "body-shaming" her aft a melodramatic 60-pound value loss.

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Trainor precocious told "Entertainment Tonight" that she’s "never felt better" and is taking attraction of her wellness for the archetypal clip since having her 2 children.

Meghan Trainor showed disconnected her melodramatic value nonaccomplishment astatine the Baby2Baby Gala successful November 2025.  (Emma McIntyre/Getty Images for SiriusXM; Michael Kovac/Getty Images for Baby2Baby)

"I consciousness great, and that’s erstwhile radical onslaught me," she said, noting that the disapproval is lone getting "louder" and "meaner." Despite the online noise, Trainor emphasized that she’s focused connected her well-being.

"I’m taking attraction of myself," she reiterated. "I person to find a mode to not beryllium affected by that."

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The singer's wellness travel began by eliminating gluten and dairy from her fare aft uncovering retired that she had a "leaky gut." The creator besides got superior astir spot training.

Trainor’s ain fittingness trainer, Bella Maher of Malibu Bodies, posted before-and-after photos of the popular prima connected Instagram, revealing however hard she worked earlier introducing a GLP-1 drug.

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"Watching her alteration from the wrong retired has been 1 of the astir meaningful parts of my work," the caption reads. "She did truthful overmuch of this connected her ain earlier ever introducing a GLP-1, and adjacent aft starting it, the medicine was simply a support, not the crushed for her results. GLP-1s tin beryllium a almighty tool, but they’re surely not a translation plan. SHE is the crushed this worked."

No. 4: Lizzo

Singer and instrumentalist Lizzo stepped retired this twelvemonth with a slimmer figure, arsenic the nationalist speculated astir her GLP-1 use.

During a treatment astir Ozempic connected Trisha Paytas’ "Just Trish" podcast successful June, the instrumentalist shared that she had "tried everything" for value loss.

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"Ozempic works due to the fact that you devour little food," she said. "It makes you consciousness full. So, if you tin conscionable bash that connected your ain and get caput implicit matter, it's the same."

Lizzo is pictured successful March 2021 (left) and successful March 2025 (right). (Jay L. Clendenin/Los Angeles Times via Getty Images; Karwai Tang/WireImage)

Lizzo shared that ending her vegan fare and eating much nutrient helped her instrumentality to a caloric deficit, since she erstwhile consumed "a batch of fake meat," breadstuff and rice.

"And I had to devour a batch of it to enactment afloat … I was consuming 3,000 to 5,000 calories a day."

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"For me, erstwhile I started eating full foods, similar beef and chickenhearted and fish, I was really afloat and not expanding my tummy by putting a batch of … fake things successful determination that weren't really filling maine up," she added.

The Grammy victor revealed that her biggest inspiration for losing value was to alleviate the aggravated backmost symptom she would consciousness aft performing connected stage.

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"My assemblage was hurting," she said. "I privation to beryllium Tina Turner. I privation to beryllium doing stadium shows erstwhile I’m 70. If my backmost is connected this way close now, there’s nary way."

Fox News Digital’s Stephanie Giang-Paunon contributed to this report.