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MarketBeat
Fri, March 27, 2026 astatine 9:07 AM CDT 9 min read
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Autolus said its commercialized motorboat of AUCATZYL produced $74.3 million successful 2025 revenue, the institution finished the twelvemonth with 67 activated U.S. centers, reiterated 2026 nett merchandise gross guidance of $120–$135 million, and expects to transcend 80 activated centers and execute affirmative gross margins successful 2026 pursuing EU/U.K. approvals and a U.K. launch.
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Real‑world ROCCA information showed an aboriginal day‑28 implicit remission complaint of astir 92% and information accordant with anterior FELIX proceedings results (≈59% people 1–2 CRS with nary people ≥3 CRS; 17% people 1–2 ICANS, 3% people 3 ICANS).
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Financially, Q4 merchandise gross was $23.3 cardinal (FY $74.3M), the institution revised gross designation to grounds afloat merchandise income upon second‑dose confirmation, and reported $300.7 million successful currency and equivalents—management says this funds operations into Q4 2027.
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Autolus Therapeutics (NASDAQ:AUTL) executives highlighted a “very bully archetypal twelvemonth of launch” for AUCATZYL during the company’s fourth-quarter and full-year 2025 fiscal results call, pointing to $74.3 cardinal successful gross recognized successful 2025, expanded U.S. treatment-center activation, and aboriginal real-world outcomes that absorption said aligned good with anterior objective proceedings results.
Chief Executive Officer Dr. Christian Itin said the institution ended 2025 with 67 activated centers and plans to grow its commercialized footprint to much than 80 activated centers by the extremity of 2026. Autolus reiterated its 2026 nett merchandise gross guidance of $120 cardinal to $135 cardinal and said it expects to displacement to affirmative gross margins successful 2026.
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Itin attributed the expected gross borderline betterment to higher volumes that trim fixed costs and operating-model improvements that little adaptable costs per manufacturing batch. He besides noted that Autolus achieved regulatory approvals successful the EU and the U.K. by the extremity of 2025, gained marketplace entree successful the U.K., and initiated a motorboat determination astatine the opening of 2026.
In effect to expert questions, absorption said 2026 gross guidance includes contributions from the U.S. and U.K. but that it does not program to interruption retired the expected U.K. contribution. Itin characterized the U.K. arsenic “substantially smaller” than the U.S. and said Autolus does not expect a large publication yet fixed the aboriginal signifier of the U.K. launch. For the EU, Itin said the institution does not expect gross contributions from different EU countries successful 2026 and is successful discussions with marketplace entree authorities, emphasizing the request to participate markets successful an “economically sensible” way.
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